Anti-MUC1-C antibodies and CAR-T structures
AssigneeTeneoBio, Inc.
InventorsKatherine Harris, Brian Avanzino, Nathan Trinklein, Karen Chang, Nicole Allen
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Abstract
Anti-MUC1-C antibodies (e.g., UniAbs™) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of MUC1-C.
Claims13
An isolated antibody that binds to MUC1-C, comprising a heavy chain variable region comprising:
- (a) a CDR1 sequence of SEQ ID NO:
- 1, a CDR2 sequence of SEQ ID NO:
- 2, and a CDR3 sequence of SEQ ID NO:
- 3;
- or
- (b) a CDR1 sequence of SEQ ID NO:
- 4, a CDR2 sequence of SEQ ID NO:
- 5, and a CDR3 sequence of SEQ ID NO:
- 6.
A CAR-T cell comprising a CAR comprising an extracellular antigen-binding domain that binds to MUC1-C, comprising a heavy chain variable region comprising:
- (a) a CDR1 sequence of SEQ ID NO:
- 1, a CDR2 sequence of SEQ ID NO:
- 2, and a CDR3 sequence of SEQ ID NO:
- 3;
- or
- (b) a CDR1 sequence of SEQ ID NO:
- 4, a CDR2 sequence of SEQ ID NO:
- 5, and a CDR3 sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.