Immunoglobulin single domain antibodies for delivery of mucosal vaccines
AssigneesUniversiteit Gent, Vib Vzw
InventorsEric Cox, Bert Devriendt, Anna Depicker
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Abstract
The present invention relates to single-domain antibodies that specifically bind aminopeptidase N (APN), and more in particular to polypeptides, and nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the single-domain antibodies of the present invention are capable of targeting a moiety to a mucosal surface.
Claims16
A polypeptide comprising at least one immunoglobulin single variable domain (ISVD), the ISVD comprising three complementarity determining regions (CDR), wherein:
- (i) CDR1 is SEQ ID NO:
- 1, CDR2 is SEQ ID NO:
- 3, and CDR3 is SEQ ID NO:
- 4;
- or
- (ii) CDR1 is SEQ ID NO:
- 2, CDR2 is SEQ ID NO:
- 3, and CDR3 is SEQ ID NO:
- 5;
- wherein the ISVD specifically binds CD13 and is internalized by CD13-expressing cells.
Dependencies are inferred from the claim text.