Humanized anti-human CD89 antibodies and uses thereof

A humanized anti-human CD89 antibody that binds an extracellular part of human CD89, comprising a heavy chain variable region comprising an amino acid sequence:

• (SEQ ID NO:
• 144)
• EVQLLESGGG LVQPGGSLRL SCAASGLTFS SYGMSWVRQA
• PGKGLEX1VX2T IX3GX4GDITYY PDSVKGRFTI SRDNSKNTLY
• TAVYYCARDY LQMNSLRAED DYDYAMDYWG QGTLVTVSS,
• wherein:
• X1 is L or W
• X2 is A or S
• X3 is N or S
• X4 is Q, T or N,
• wherein said heavy chain variable region comprises 0, 1 or 2 amino acid insertions, deletions or substitutions with respect to SEQ ID NO:
• 144, or a combination thereof at positions other than X1, X2, X3 and X4,
• wherein the 0, 1 or 2 amino acid insertions, deletions or substitutions, or the combination thereof, are not within a complementary determining region (CDR),
• wherein the amino acid sequence of CDR1 is SYGMS (SEQ ID NO:
• 45), wherein the amino acid sequence of CDR2 is TINGNGDITYYPDSVKG (SEQ ID NO:
• 46), TISGQGDITYYPDSVKG (SEQ ID NO:
• 147), or TISGTGDITYYPDSVKG (SEQ ID NO:
• 148), and wherein the amino acid sequence of CDR3 is DYDYDYAMDY (SEQ ID NO:
• 47), and a light chain variable region comprising an amino acid sequence:
• (SEQ ID NO:
• 145)
• DIQMTQSPSS LSASVGDRVT ITCRASQDII NYLNWYQQKP
• GKZ1Z2KLLIYY TSRLHSGVPS RFSGSGSGTD Z3TLTISSLQP
• EDFATYZ4CQQ GKTLPYTFGQ GTKLEIK,
• wherein:
• Z1 is A or T
• Z2 is V or P
• Z3 is Y or F
• Z4 is Y or F,
• wherein said light chain variable region comprises 0, 1 or 2 amino acid insertions, deletions or substitutions with respect to SEQ ID NO:
• 145, or a combination thereof at positions other than Z1, Z2, Z3 and Z4,
• wherein the 0, 1 or 2 amino acid insertions, deletions or substitutions, or the combination thereof, are not within a CDR region,
• wherein the amino acid sequence of CDR1 is RASQDIINYLN (SEQ ID NO:
• 48), wherein the amino acid sequence of CDR2 is YTSRLHS (SEQ ID NO:
• 49), and wherein the amino acid sequence of CDR3 is QQGKTLPYT (SEQ ID NO:
• 50).