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US 12,735,483 B2Granted
Anti-TIGIT antibodies and methods of use
AssigneeIndustrial Technology Research Institute
InventorsMin-Yuan Chou, Li-Tsen Lin, Chung-Yuan Sun, Ya-Ping Lai, Chin-Pen Lai, Ssu-Yuan Wu, Mei-Wei Lin
Life of this patent
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Abstract
Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.
Claims9
An isolated antibody or antigen-binding fragment that specifically binds to human T cell immunoglobulin and ITIM domain (TIGIT), wherein the antibody or antigen-binding fragment comprises:
- three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:
- 1 (HCDR1), SEQ ID NO:
- 2 (HCDR2), and SEQ ID NO:
- 3 (HCDR3);
- three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:
- 4 (LCDR1), SEQ ID NO:
- 5 (LCDR2), and SEQ ID NO:
- 23 (LCDR3);
- a heavy chain variable region that is at least 91% identical to an amino acid sequence of SEQ ID NO:
- 39;
- and
- a light chain variable region that is at least 91% identical to an amino acid sequence of SEQ ID NO:
- 40.
10 more elements
Dependencies are inferred from the claim text.