Polypeptide derivative having dual receptor agonistic action and use thereof

Abstract

The present invention provides a polypeptide derivative, or a modified derivative or salt thereof, and use of the polypeptide derivative, or the modified derivative or salt thereof. The polypeptide derivative, or the modified derivative or salt thereof comprises a polypeptide having the sequence of the following general formula I: general formula I: HX2QGTFTSDX10SKYLX15EX17X18AX20X21FX23AWLEX28X29X30, wherein the definitions of X2, X10, X15, X17, X18, X20, X21, X23, X28, X29, and X30 are consistent with those in the claims and description. The polypeptide derivatives of the present invention are dual agonists for GC/GLP-1 receptor, have a synergic effect on energy metabolism, can effectively reduce weight and improve a body fat level while reducing blood glucose, and have a potential application value in the field of treatment of metabolic diseases such as diabetes and obesity.

Dependencies are inferred from the claim text.