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US 12,735,463 B2Granted
Peptide tags for ligand induced degradation of fusion proteins
AssigneesDana-Farber Cancer Institute, Inc., The General Hospital Corporation
InventorsEric Fischer, Benjamin L. Ebert, Max Jan, Radoslaw Nowak
Life of this patent
Estimating the term…
Abstract
Described herein are compositions and methods for modulating protein abundance in a target-specific manner via degron tags.
Claims24
A degron tag comprising a non-naturally occurring peptide which has the amino acid sequence of any one of
- (SEQ ID NO:
- 153)
- FQCQVCGARFSRWEELYNHLLKH,
- (SEQ ID NO:
- 154)
- FQCEMCGAAFDRWEELYNHKNAH,
- (SEQ ID NO:
- 155)
- FQCEICGARFKRWEELYNHLKKH,
- (SEQ ID NO:
- 156)
- FQCEICGAAFSRWEELYNHLKRH,
- (SEQ ID NO:
- 157)
- FQCEICGARFFRWEELYNHLAKH,
- (SEQ ID NO:
- 158)
- FQCSICGATFSRWEELYNHLLKH,
- (SEQ ID NO:
- 159)
- FQCEICGARFSRWEELYNHLNKH,
- (SEQ ID NO:
- 160)
- FQCEICGAKFENWEDLYNHLLKH,
- (SEQ ID NO:
- 161)
- FQCKQCGAVFSRWEELYNHLTNH,
- (SEQ ID NO:
- 162)
- FQCKQCGAVFSRWEELYNHLKNH,
- (SEQ ID NO:
- 163)
- FQCKQCGAVFKRWEELYNHLLAH,
- (SEQ ID NO:
- 164)
- FQCEICGARFSRWEELYNHLLKH,
- (SEQ ID NO:
- 165)
- FQCQVCGARFSRWEELYNHLSKH,
- (SEQ ID NO:
- 166)
- FQCQYCGARFNRWEELYDHLNKH,
- (SEQ ID NO:
- 167)
- FQCQMCGAAFDRWEELYNHLLAH,
- (SEQ ID NO:
- 168)
- FQCVQCGARFNRWEELYDHLNKH,
- (SEQ ID NO:
- 169)
- FQCKYCGAVFSRWEELYNHLLAH,
- (SEQ ID NO:
- 170)
- FQCEICGARFSRWEELYNHLKNH,
- (SEQ ID NO:
- 171)
- FQCNQCGASFTRWEELYNHLLRH,
- (SEQ ID NO:
- 172)
- FQCQYCGAVFTRWEELYNHLLRH,
- (SEQ ID NO:
- 173)
- FQCSQCGAAFNRWEELYNHLLRH,
- (SEQ ID NO:
- 174)
- FQCDKCGAKFDRWEELYNHNNAH,
- (SEQ ID NO:
- 175)
- FQCEICGARFENWEDLYNHLLKH,
- (SEQ ID NO:
- 176)
- FTCTACGATFTRAEELNTHLSKH,
- (SEQ ID NO:
- 177)
- FQCEYCGARFNRWEELYNHLLKH,
- (SEQ ID NO:
- 178)
- YQCEICGARFNRWEELYNHLKNH,
- (SEQ ID NO:
- 179)
- FQCEICGAAFSRWEELYNHLLAH,
- (SEQ ID NO:
- 180)
- FQCEICGARFSRWEELYNHLSKH,
- (SEQ ID NO:
- 181)
- FQCEICGARFEYWEQLYNHLKNH,
- (SEQ ID NO:
- 182)
- FYCTQCGAAFDRWEELYNHLLNH,
- (SEQ ID NO:
- 183)
- MQCEICGFTCRRAEELNTHLNKH, or
- (SEQ ID NO:
- 184)
- FYCKQCGANFSRWEELYNHLKAH.
93 more elements
Dependencies are inferred from the claim text.