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US 12,735,458 B2Granted
Self-assembled peptide nanorods and uses thereof
AssigneeDéVeloppement Mondial Nanotech Inc.
InventorsSteve Bourgault, Denis Archambault, Ximena Zottig, Soultan Al-Halifa
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Abstract
Self-assembling, cytocompatible peptides having the ability to form uniform nanorod assemblies are described. These peptides comprise a self-assembling β-sheet peptide and an amino terminal positively charged amino acid or amino acid analog, such as a lysine residue. Constructs comprising an antigen covalently attached to the self-assembling peptide are also disclosed, as well as the use of such constructs as vaccines for inducing an immune response against the antigen.
Claims20
A construct comprising:
- i) a self-assembling domain of the formula:
- X1-X2-L1-Z
- wherein
- X1 is a lysine residue or an analog thereof comprising a primary amine in its side chain, or is absent;
- X2 is a lysine residue or an analog thereof comprising a primary amine in its side chain;
- L1 is a peptide linker of 2 to 8 amino acids;
- Z is a self-assembling amyloid peptide;
- and
- ii) a molecule conjugated to the self-assembling domain.
6 more elements
Dependencies are inferred from the claim text.