Peptide compound targeting elastin-derived peptides and use thereof
AssigneeShenzhen Turier Biotech Co. Ltd.
InventorsXianxing Jiang, Rui Wang, Nazi Song
Life of this patent
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Abstract
The present invention relates to peptide compound targeting elastin-derived peptides and use thereof. The peptide comprises a parent peptide represented by the following amino acid sequence: R1-Val-Xa2-Gly-Ser-Pro-Ser-Ala-Gln-Xa9-Xa10-Ala-Ser-Pro-Xa14, and is characterized by better biological activity, higher safety and stability, high synthesis yield, low cost, etc. The peptide compound may be used for treating hepatic fibrosis and fibrotic conditions accompanying hepatic disease as well as idiopathic pulmonary fibrosis and fibrotic conditions accompanying pulmonary disease.
Claims9
A peptide compound targeting elastin-derived peptides comprising a parent peptide represented by the following amino acid sequence:
- R1-Val-Xa2-Gly-Ser-Pro-Ser-Ala-Gln-Xa9-Xa10-Ala-Ser-Pro-Xa14,
- wherein,
- R1 is a lipophilic substituent or is absent;
- Xa2=Val or Iva;
- Xa9=Asp or Glu;
- Xa10=Glu or Asp;
- Xa14=Ala.
Dependencies are inferred from the claim text.