US 12,735,431 B2 · 7-phenyl substituted 2-aminoquinazoline inhibitors of HPK1

Abstract

Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

A compound which is selected from the group consisting of:

7-(5-amino-4-methylpyridin-3-yl)-6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
methyl (3-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-4-methoxyphenyl)acetate;
6-fluoro-N~2~-(6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(3-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-4-methoxyphenyl)acetonitrile;
4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3-methoxybenzene-1-sulfonamide;
1-[6-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3,4-dihydroquinolin-1 (2H)-yl]ethan-1-one;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[2-(trifluoromethoxy)phenyl]quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(pyridin-3-yl)quinazoline-2,5-diamine;
(R or S)—N-(5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-2,3-dihydro-1H-inden-1-yl)acetamide;
(R or S)—N-(5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-2,3-dihydro-1H-inden-1-yl)acetamide;
1-[7-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxy-3,4-dihydroisoquinolin-2 (1H)-yl]ethan-1-one;
2-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-N-methylacetamide;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[3-(methylsulfonyl)phenyl]quinazoline-2,5-diamine;
N-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)acetamide;
N-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)methanesulfonamide;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[4-(methylsulfonyl)phenyl]quinazoline-2,5-diamine;
1-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)cyclopropane-1-carbonitrile;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(pyrimidin-5-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(4-methoxypyridin-3-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
7-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one;
6-fluoro-N~2~-(2-fluorophenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-N-methylbenzamide;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[(methylsulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-phenylquinazoline-2,5-diamine;
N~2~-(2-cyclopropylphenyl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(2-methoxypyridin-3-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)-1-[2-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)pyrrolidin-1-yl]ethan-1-one;
(R or S)-1-[2-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)pyrrolidin-1-yl]ethan-1-one;
N-[(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)methyl]acetamide;
N~2~-(2-chlorophenyl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methylpyridin-3-yl)quinazoline-2,5-diamine;
3-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-N-tert-butylbenzene-1-sulfonamide;
3-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-N-methylbenzene-1-sulfonamide;
(R or S)-6-fluoro-N~2~-(6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)-6-fluoro-N~2~-(6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
N~2~-(6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(4-methylpyridin-3-yl)quinazoline-2,5-diamine;
7-(2-fluoro-6-methylphenyl)-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
7-(5-amino-4-methylpyridin-3-yl)-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1 (3H)-one;
5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-2-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-isoindol-1-one;
5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-2,3-dihydro-1H-1-benzothiophene-1,1-dione;
6-fluoro-7-(4-methylpyridin-3-yl)-N~2~-{4-[(methylsulfonyl)methyl]phenyl}-quinazoline-2,5-diamine;
6-fluoro-N~2~-(6′-methoxy-2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R and S)-(7-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol;
6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-([1,3]thiazolo[4,5-b]pyridin-6-yl)quinazoline-2,5-diamine;
(R,R and S,S)-6-fluoro-N~2~-(6-methoxy-1,2,3-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-(5-amino-6-fluoro-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)quinazolin-7-yl)-5-methylbenzo[d]oxazol-2 (3H)-one;
6-fluoro-N2-(2-methoxy-4-((methylsulfonyl)methyl)phenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
3-(5-amino-6-fluoro-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)quinazolin-7-yl)-4-methylbenzonitrile;
3-(5-amino-6-fluoro-2-{[4-(methylsulfonyl)phenyl]amino}quinazolin-7-yl)-4-methylbenzonitrile;
3-[5-amino-6-fluoro-2-({4-[(methylsulfonyl)methyl]phenyl}amino)quinazolin-7-yl]-4-methylbenzonitrile;
(R or S)-3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3-methoxyphenyl)-1-methylpyrrolidin-2-one;
(R or S)-6-fluoro-N~2~-{2-methoxy-4-[1-(methylsulfonyl)ethyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)-6-fluoro-N~2~-{2-methoxy-4-[1-(methylsulfonyl)ethyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)-3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3-methoxyphenyl)-1-methylpyrrolidin-2-one;
4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-N-(3-methoxycyclobutyl)benzamide;
6-fluoro-N~2~-(6-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-[2-methyl-4-(1,3-oxazol-2-yl)phenyl]quinazoline-2,5-diamine;
6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-[4-methyl-6-(1,3-oxazol-2-yl)pyridin-3-yl]quinazoline-2,5-diamine;
(R or S)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[1-(methylsulfonyl)ethyl]phenyl}quinazoline-2,5-diamine;
(R or S)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[1-(methylsulfonyl)ethyl]phenyl}quinazoline-2,5-diamine;
N~2~-(6-chloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-[2-(1-methyl-1H-pyrazol-5-yl)phenyl]quinazoline-2,5-diamine;
6-fluoro-N~2~-(2-methoxy-6-methylpyridin-3-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-1,3-oxazolidin-2-one;
1-(5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxypyridin-2-yl)cyclopropane-1-carbonitrile;
6-fluoro-N~2~-(4-fluoro-2-methoxyphenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(2-methoxyphenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-[6-methoxy-2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3-methoxy-N-methylbenzamide;
6-fluoro-N~2~-(6-methoxy-2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]quinazoline-2,5-diamine;
6-fluoro-N~2~-(6-methoxy-2-methylpyridin-3-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-2-methyl-2,3-dihydro-1H-isoindol-1-one;
(R,S and S,R)-6-fluoro-N2-(2-methyl-1,2,3,4-tetrahydro-1,4-methanoisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
1-(4-((5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl)amino)phenyl)-N-methylcyclohexane-1-carboxamide;
1-(4-((5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl)amino)phenyl)-N-methylcyclopropane-1-carboxamide;
1-(4-((5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl)amino)phenyl)-N-methylcyclobutane-1-carboxamide;
1-(4-((5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl)amino)phenyl)-N-methylcyclopentane-1-carboxamide;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(6-((methylsulfonyl)methyl)pyridin-3-yl)quinazoline-2,5-diamine;
(R or S)—N2-(2,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)—N2-(2,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
7-((5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroisoquinoline-6-carboxamide;
6-fluoro-N2-(7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
N2-(4-((ethylsulfonyl)methyl)phenyl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[(methylsulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[(methylsulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N~2~-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]quinazoline-2,5-diamine;
(+ and −)-4-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3-methoxy-N-methylbenzamide;
(+ and −)-4-{[5-amino-8-chloro-7-(6-chloro-8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoroquinazolin-2-yl]amino}-3-methoxy-N-methylbenzamide;
(+ or −)-8-chloro-6-fluoro-N~2~-{2-methoxy-4-[(methylsulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N~2~-{2-methoxy-4-[(methylsulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N~2~-[6-methoxy-2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[4-(methylsulfonyl)phenyl]quinazoline-2,5-diamine;
8-chloro-6-fluoro-N2-(6-methoxy-2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N2-(2-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N2-(2-isopropyl-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N2-(6-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N2-(2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-5-amino-6-fluoro-2-((2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-8-carbonitrile;
(+ and −)-6-fluoro-8-methyl-N2-(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-bromo-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]quinazoline-2,5-diamine;
6-fluoro-N~2~-{3-fluoro-4-[(methanesulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[(pyrrolidine-1-sulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)propanenitrile;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl)quinazoline-2,5-diamine;
N~2~-(3,4-dihydro-1H-2-benzopyran-7-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(9-methyl-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-6-yl)quinazoline-2,5-diamine;
6-fluoro-7-(4-methylpyridin-3-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
7-(8-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N~2~-{4-[(methylsulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
7-(8-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(R or S)-7-(3,8-dimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(4-((ethylsulfonyl)methyl)-2-fluorophenyl)-6-fluoroquinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(2,3,3-trimethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(2,3,3-trimethyl-1,2,3,4-tetrahydroisoquinolin-5-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(2,3,3-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(R or S)-7-(3,8-dimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N2-(4-((ethylsulfonyl)methyl)-2-fluorophenyl)-6-fluoroquinazoline-2,5-diamine;
6-fluoro-7-(7-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-N~2~-{2-fluoro-4-[(methylsulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-N~2~-{4-[(cyclopropylsulfonyl)methyl]phenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(4-{[(propan-2-yl)sulfonyl]methyl}phenyl)quinazoline-2,5-diamine;
8-chloro-N~2~-{4-[(ethylsulfonyl)methyl]phenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
8-chloro-6-fluoro-N~2~-{2-fluoro-4-[(methylsulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
N~2~-{4-[(cyclopropylsulfonyl)methyl]phenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-N~2~-{4-[(cyclopropylsulfonyl)methyl]phenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-3,4-dihydro-2-benzothiopyran-2,2 (1H)-dione;
6-fluoro-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(1H-pyrrolo[2,3-c]pyridin-4-yl)quinazoline-2,5-diamine;
8-chloro-N~2~-{4-[(ethylsulfonyl)methyl]phenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(R or S)-7-(3,8-dimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(6-methyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl)quinazoline-2,5-diamine;
N~2~-{4-[(ethylsulfonyl)methyl]-2-fluorophenyl}-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
N~2~-{4-[(ethylsulfonyl)methyl]-2-fluorophenyl}-6-fluoro-7-(3,3,8-trimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
7-(3,8-dimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N2-(2-isopropyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(R or S)-3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-1-methylpyrrolidin-2-one;
(R or S)-3-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-1-methylpyrrolidin-2-one;
6-fluoro-N~2~-{4-[1-(methanesulfonyl)cyclopropyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-{4-[(2,2,2-trifluoroethanesulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
7-(2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N~2~-(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
7-(8-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N~2~-(2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
7-(5-amino-4-methylpyridin-3-yl)-6-fluoro-N~2~-(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)quinazoline-2,5-diamine;
N~2~-(4,4-difluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-{2-fluoro-4-[(methylsulfonyl)methyl]phenyl}-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
3-(4-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-1,3-oxazolidin-2-one;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(4-{[(propan-2-yl)sulfonyl]methyl}phenyl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)quinazoline-2,5-diamine;
3-(4-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-1,3-oxazolidin-2-one;
7-(8-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-6-fluoro-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N~2~-{4-[(methylsulfonyl)methyl]phenyl}-7-(3,3,8-trimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(7-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
8-chloro-6-fluoro-N~2~-(6′-methoxy-2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
1-(4-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-2-methylpropan-2-ol;
6-fluoro-N~2~-{4-[(methylsulfonyl)methyl]phenyl}-7-(3,3,8-trimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(3,3,8-trimethyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
1-(4-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-2-methylpropan-2-ol;
6-fluoro-N~2~-(2-methoxy-4-{[(propan-2-yl)sulfonyl]methyl}phenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
8-chloro-6-fluoro-N~2~-(6′-methoxy-2′-methyl-2′,3′-dihydro-l′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[4-(methylsulfinyl)phenyl]quinazoline-2,5-diamine;
6-fluoro-N~2~-[6-fluoro-2-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(5-fluoro-2-methylphenyl)-N~2~-{4-[(methylsulfonyl)methyl]phenyl}quinazoline-2,5-diamine;
N~2~-(6-ethylpyridin-3-yl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(5-fluoro-2-methylphenyl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-[6-(propan-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl]quinazoline-2,5-diamine;
N~2~-(4-cyclopropyl-2-methoxyphenyl)-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
6-fluoro-N~2~-(2-methoxy-4-methylphenyl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
1-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-2-methylpropan-2-ol;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(+ or −)-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)quinazoline-2,5-diamine;
(+ or −)-1-(5-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxypyridin-2-yl)cyclopropane-1-carbonitrile;
(+ or −)-1-(5-{[5-amino-8-chloro-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-6-methoxypyridin-2-yl)cyclopropane-1-carbonitrile;
6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N~2~-(6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N~2~-(6-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
(+ and −)-8-chloro-6-fluoro-N~2~-(6-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazoline-2,5-diamine;
2-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-2,2-difluoro-N-methylacetamide;
2-(4-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}phenyl)-N,2-dimethylpropanamide;
5-{[5-amino-6-fluoro-7-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)quinazolin-2-yl]amino}-N-methyl-2,3-dihydro-1H-indene-1-carboxamide;
or a pharmaceutically acceptable salt thereof.

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7-phenyl substituted 2-aminoquinazoline inhibitors of HPK1

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7-phenyl substituted 2-aminoquinazoline inhibitors of HPK1

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Abstract

Claims2