Rock inhibitor and preparation method therefor and use thereof

A compound of formula (I) or a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, a nitrogen oxide, a solvate, a polymorph, a pharmaceutically acceptable salt thereof,

• wherein,
• ring B is attached to the X via an N atom present on the ring B;
• and
• is selected from the following groups unsubstituted or optionally substituted with one, two or more Rab:
• X is —C(═O) NRx-;
• Y is methylene unsubstituted or optionally substituted with one, two or more Ry;
• ring C is the following group unsubstituted or optionally substituted with one, two or more Rc:
• phenyl, pyridinyl, pyrazolyl, imidazolyl, and benzimidazolyl;
• ring D is pyrazolyl or triazolyl unsubstituted or optionally substituted with one, two or more Rd;
• each Ry is independently H, halogen, OH, or the following group unsubstituted or optionally substituted with one, two or more R:
• methyl, ethyl, propyl, butyl, pentyl, hexyl, NH2(CH2)m—, (CH3)2N(CH2)m—, CH3NH(CH2)m—, oxetanyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, pyrrolyl, piperidyl,
• wherein each m is independently selected from 0, 1, 2 and 3;
• wherein each R is independently ═O, halogen, CN, OH, SH, NH2, or the following group unsubstituted or optionally substituted with one, two or more R′:
• 3-7 membered heterocyclyl containing one heteroatom which is selected from nitrogen or oxygen;
• wherein each R′ is independently halogen or (C1-C6) aliphatic hydrocarbyl;
• each Rab is H, halogen, CN, or (C1-C6) aliphatic hydrocarbyl, wherein the (C1-C6) aliphatic hydrocarbyl is unsubstituted or optionally substituted with one, two or more halogen;
• each Rc is independently H, halogen, —C(O)NR11R12, or the following group unsubstituted or optionally substituted with one, two or more R:
• methyl, ethyl, propyl, butyl, pentyl, hexyl, methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, —O(CH2)nO(CH2)mCH3, NH2(CH2)m—, (CH3)2N(CH2)m—, CH3NH(CH2)m—, —(NH)kC(O)NH2, —(NH)kC(O)NH(CH2)mCH3, —(NH)kC(O)N(CH3)(CH2)mCH3, —(NH)kC(O)(CH2)mCH3, —OC(O)(CH2)mCH3, —O(CH2)mC(═O)(CH2)m(NH)kH, or —C(O)O(CH2)mCH3, wherein each n is independently selected from 1, 2 and 3;
• each m is independently selected from 0, 1, 2 and 3;
• each k is independently selected from 0 and 1;
• wherein each R is independently ═O, halogen, CN, OH, SH, NH2, or the following group unsubstituted or optionally substituted with one, two or more R′:
• 3-7 membered heterocyclyl containing one heteroatom selected from nitrogen and oxygen, (C1-C6) aliphatic hydrocarbyl, or C3-7 alicyclic hydrocarbyl;
• wherein each R′ is independently halogen or (C1-C6) aliphatic hydrocarbyl;
• and wherein R11 is H or C3-7 alicyclic hydrocarbyl and R12 is H or C3-7 alicyclic hydrocarbyl;
• each Rd is independently H, halogen, —NH2, or (C1-C6) aliphatic hydrocarbyl, wherein the (C1-C6) aliphatic hydrocarbyl is unsubstituted or optionally substituted with one, two or more halogen;
• and
• each Rx is independently selected from H, halogen, and the following groups unsubstituted or optionally substituted with one, two or more halogen:
• methyl, ethyl, propyl, butyl, pentyl, hexyl, vinyl, propenyl, butenyl, pentenyl, hexenyl, NH2(CH2)m—, (CH3)2N(CH2)m—, CH3NH(CH2)m—, oxetanyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, pyrrolyl, piperidyl, wherein each m is selected from 0, 1, 2, and 3.