Small molecule antagonists for the relaxin-3/RXFP3 system

A compound having inhibitory activity for the relaxin family peptide 3 receptor (RXFP3), optionally wherein the compound has a half maximal inhibitory concentration IC50 for RXFP3 in the presence of relaxin-3 of about 10 micromolar (μM) or less, wherein the compound has a structure of Formula (I):

• wherein:
• L is
• n is an integer between 1 and 3;
• RL is selected from the group comprising hydrogen, C1-C6 substituted or unsubstituted alkyl, C2-C6 substituted or unsubstituted alkenyl, C3-C6 substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclo, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• m is an integer between 0 and 3;
• p is an integer between 0 and 3;
• q is an integer between 0 and 3;
• A is selected from phenyl and pyridinyl;
• B is a five-membered heterocyclic group;
• D is selected from substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• R1 is selected from the group consisting of hydrogen, C1-C6 substituted or unsubstituted alkyl, C2-C6 substituted or unsubstituted alkenyl, C3-C6 substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclo, substituted or unsubstituted aryl, and substituted or unsubstituted 5- or 6-membered heteroaryl;
• each R2 is independently selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C6 alkenyl, C1-C6 substituted or unsubstituted cycloalkyl, C1-C6 alkoxy;
• substituted or unsubstituted heterocyclo, halo, nitro, cyano, amino, alkylsulfonyl, ester and amide;
• and
• each R3 is independently selected from C1-C6 substituted or unsubstituted alkyl, C2-C6 substituted or unsubstituted alkenyl, C3-C6 substituted or unsubstituted cycloalkyl, C1-C6 alkoxy, substituted or unsubstituted heterocyclo, halo, nitro, cyano, amino, alkylsulfonyl, ester, and amide;
• or a pharmaceutically acceptable salt thereof.