Dihydro-cyclopenta-isoquinoline

A compound of general formula (I) or a pharmaceutically acceptable salt thereof,

• Wherein:
• R1 represents:
• Hydroxy;
• Amino;
• —NH—C(O)—Ra1;
• —NH—C(O)—NH—Rb1;
• —NH—C(O)—C1-6-alkanediyl-C(O)—C1-6-alkoxy optionally substituted with one or more aryl substituted with one or more halogen, —OH, or C1-6-alkyl;
• —NH—C(O)—C1-6-alkanediylC(O)-aryl optionally substituted with one or more hydroxy;
• halogen;
• or
• C1-6-alkyl;
• —NH—C(O)—C1-6-alkanediyl-NHC(O)-aryl optionally substituted with one or more hydroxy;
• halogen;
• or C1-6-alkyl;
• —NH—C(O)—C1-6-alkanediyl-aryloxy optionally substituted with one or more hydroxy;
• halogen;
• or
• C1-6-alkyl;
• —NH—C(O)—NH—C(O)O—C1-6-alkyl;
• —NH-Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or heteroaryl;
• —NH—C(S)—NH-Rc1;
• —NH-Aryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or heteroaryl;
• —NH—C(O)O-Rd1;
• —NH—C(N—CN)—NH—C1-6-alkyl;
• or
• Heteroaryl optionally substituted with one or more C1-6-alkyl, C1-6-alkylamino;
• or heteroarylamino;
• wherein
• Ra1 represents
• C1-6-alkyl optionally substituted with one or more Aryl or Heteroaryl, each of which is optionally substituted with Halogen;
• C1-6-alkoxy;
• or cyano;
• Aryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• or C1-6-akylamino;
• Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or heterocycloalkyl;
• —C2-6-alkenediyl-aryl optionally substituted with one or more C1-6-alkyl;
• or Halogen;
• —R1′C(O)OR1″ group, wherein R1″ is alkyl and R1′ is alkanediyl;
• C3-8-cycloalkyl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or
• C3-8-heterocycloalkyl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• or cyano;
• Rb1 represents
• C1-6-alkyl optionally substituted with aryl optionally substituted with one or more Halogen,
• C1-6-alkoxy;
• heteroaryl which is optionally substituted with one or more Halogen;
• C1-6-alkyl;
• or C1-6-alkoxy;
• C3-12-cycloalkyloptionally substituted with one or more C1-6-alkyl group, or aryl;
• Aryl optionally substituted with one or more cyano;
• C2-6-alkenediyl-aryl optionally substituted with one or more Halogen;
• C1-6-alkyl;
• —OH;
• Aryl substituted with one or more Halogen;
• C1-6-alkyl;
• or —OH;
• Heteroraryl optionally substituted with one or more Halogen, C1-6-alkyl, or C1-6-alkoxy;
• or
• Heterocycloalkyl optionally substituted with one or more Halogen;
• C1-C6-alkoxy;
• cyano;
• or
• Amino;
• Rc1 represents
• C1-6-alkyl;
• or
• Heteroaryl;
• Rd1 represents:
• C1-6-alkyl;
• R2 represents:
• Hydroxy;
• —NH—C(O)O—C1-6-Alkyl;
• —NH—C(S)—NH—Ra2;
• —NH—C(O)—NH—Rb2;
• —NH-Aryl optionally substituted with one or more C1-6-alkoxy;
• C1-6-Alkylamino;
• heteroarylamino;
• —NH—C1-6-Alkyl optionally substituted with one or more C1-6-alkyl;
• C1-6-alkoxy;
• cyano;
• aryl;
• heteroaryl;
• C(O)O—C1-6-Alkyl group;
• C1-6-Alkylamino group;
• said substituent being optionally substituted with one or more hydroxy;
• halogen;
• oxo;
• Heteroaryl optionally substituted with one or more heteroaryl, C1-6-alkylamino or heteroarylamino;
• said heteroaryl or heteroarylamino being optionally substituted with one or more group chosen amongst amino;
• C1-6-alkyl;
• C1-6-alkylamino;
• heteroarylamino;
• —NH-Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• heteroaryl;
• C(O)OH;
• C(O)O—C1-6-Alkyl group;
• C1-6-Alkylamino group;
• Aryl-C1-6-Alkylamino;
• —C1-6-alkylamino;
• —NH—C(O)—C1-6-alkyl;
• —NH—CO-Rc2;
• —NH—C(O)—C2-6-alkenediyl-C(O)O—C1-6-Alkyl;
• —NH—C(O)—C2-6-alkenediyl-aryl optionally substituted with one or more hydroxy. C1-6-alkyl;
• Halogen;
• —NH—C(O)—C1-6-alkanediyl-heteroaryl optionally substituted with one or more oxo group;
• —NH—C(O)—C1-6-alkanediyl-heterocycloalkyl optionally substituted with one or more oxo group;
• —NHSO2—C1-6-alkyl;
• —NHSO2—Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• C(O)OH group;
• —NH—C(S)—NH—C1-6-Alkyl;
• —NHSO2—C1-6-alkoxy optionally substituted with one or more Halogen group;
• —NH—C(N—CN)—NH—C1-6-alkyl;
• or
• Amino group;
• Ra2 represents
• Heteroaryl;
• or
• C1-6-alkyl;
• Rb2 represents
• C1-6-alkyl optionally substituted with one or more Aryl;
• alkoxy-Aryl;
• or heteroaryl optionally substituted with one or more C1-6-alkyl;
• Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• or cyano;
• or
• Cycloalkyl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or aryl;
• C1-6-alkanediyl-C(O)O—C1-6-alkyl;
• Heterocycloalkyl;
• or
• Aryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• or
• C1-6-alkyl-C(O)O—C1-6-alkyl;
• Rc2 represents
• C1-6-alkyl;
• C3-8-cycloalkyl;
• C3-8-heterocycloalkyl;
• Aryl optionally substituted with one or more C1-6-alky;
• or C1-6-alkylamino;
• Heteroaryl optionally substituted with one or more Halogen;
• C1-6-alkyl, C1-6-alkoxy;
• cyano;
• heterocycloalkyl;
• Aryl;
• or amino;
• C2-6-alkenediyl-Aryl optionally substituted with one or more Halogen;
• C1-6-alkyl;
• or —OH;
• C2-6-alkanediyl-Heterocyloalkyl optionally substituted with one or more C1-6-alkyl;
• or —OH;
• C2-6-alkanediyl-C1-6-alkoxy group optionally substituted with one oxo group;
• R3 represents a group chosen amongst:
• C1-6-alkyl optionally substituted with one or more independently selected R3a;
• C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more independently selected R3a;
• C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more independently selected R3a;
• C3-6-heterocycloalkyl optionally substituted with one or more independently selected R3a;
• or
• C3-6-cycloalkyl optionally substituted with one or more independently selected R3a;
• R3a represents hydrogen Halogen, C1-2-alkyl;
• hydroxy;
• or C1-2-alkoxy;
• R4 represents:
• C3-6-cycloalkyl optionally substituted with one or more independently selected R4a group;
• C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more independently selected R4a group;
• or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more independently selected R4a group;
• and
• R4a represents a group chosen amongst hydroxy;
• Halogen;
• C1-2-alkyl.