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US 12,735,391 B2Granted
Polymorphs of Ponesimod
AssigneeTapi Czech Industries S.R.O
InventorsRohit Dwarkabhai Patel, Vinod Ramesh Borase, Anantha Rajmohan Muthusamy, Amit Singh
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Abstract
The present disclosure encompasses Ponesimod crystalline forms, processes for preparation thereof, and pharmaceutical compositions thereof.
Claims23
A crystalline form of Ponesimod, designated as Form T3, which is characterized by data selected from:
- (a) an X-ray powder diffraction pattern having peaks at 3.0, 6.0, 8.1, 9.2, 11.0, and 13.3 degrees 2-theta±0.2 degrees 2-theta;
- or
- (b) an X-ray powder diffraction pattern having peaks at 3.0, 6.0, 8.1, 9.2 and 13.3 degrees 2-theta±0.2 degrees 2-theta and missing peaks at 4.2, 6.8, 7.1, 11.7, 22.8 and 23.9 degrees 2-theta±0.2 degrees 2-theta.
A crystalline form of Ponesimod, designated Form T4, which is characterized by data selected from:
- (a) an X-ray powder diffraction pattern having broad peaks at the range of 6.3, 13.3, 18.1 and 22.1 degrees 2-theta±0.3 degrees 2-theta;
- or
- (b) an X-ray powder diffraction pattern having broad peaks at:
- 5.0-8.8, 9.0-14.5, 15.0-19.0 and 20.0-30.0 degrees 2-theta±0.3 degrees 2-theta.
1 more element
Dependencies are inferred from the claim text.