Flat self-curling sheet membranes and methods for producing same
AssigneeCollagen Matrix, Inc.
InventorsHui-Chen Chen, Natsuyo Shishido Lee, Daniel Ammon
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Abstract
A flat self-curling rollable composite sheet membrane, and methods for preparing such membranes. The sheet membrane includes a flat layer of collagen and a bioactive agent, such as a calcium phosphate-based mineral. The flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid. The methods for preparing the membranes include the steps of adding mineral to a collagen dispersion, forming a composite collagen matrix having mineral particles dispersed therein, compressing the composite matrix between two plates to form a flat sheet, and drying the flat sheet to yield a rollable composite sheet membrane.
Claims16
A flat self-curling composite sheet membrane comprising a flat layer of collagen and a bioactive agent,
- wherein the flat layer is configured to self-curl into a predetermined shape upon absorption of an aqueous fluid, and
- wherein the bioactive agent comprises at least one mineral, the at least one mineral comprising at least one of calcium sulfate, a bioactive glass, or a calcium phosphate compound, and
- wherein the ratio of the collagen to the bioactive agent is within a range of 30:70 to 5:95.
A flat self-curling composite sheet membrane consisting of a flat layer of collagen and a bioactive agent,
- wherein the flat layer is configured to self-curl into a predetermined shape upon absorption of an aqueous fluid, and
- wherein the bioactive agent consists of at least one mineral, the at least one mineral consisting of at least one of calcium sulfate, a bioactive glass, or a calcium phosphate compound, and
- wherein the ratio of the collagen to the bioactive agent is within a range of 30:70 to 5:95.
Dependencies are inferred from the claim text.