Method for manufacturing hemostatic medical material
OwnerIn Sun Jeonginventor
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Abstract
Proposed are a method of manufacturing a hemostatic medical material that has excellent biosafety and can be applied to various situations by controlling the decomposition rate as necessary, and a medical material manufactured thereby. The method includes pretreating a natural cellulose substrate by adjusting the pH of the substrate, causing the hemostatic agent to be adsorbed on the pretreated substrate, drying the substrate with the hemostatic agent adsorbed thereon, primarily modifying the dried substrate using monochloroacetic acid (MCA), secondarily modifying the primarily modified substrate using an organic acid aqueous solution, washing the secondarily modified substrate, and post treating the substrate by adjusting the pH of the washed substrate.
Claims1
A method of manufacturing a medical material, the method comprising:
- pretreating a natural cellulose substrate in the form of fiber or non-woven fabric by adjusting the pH of the natural cellulose substrate to 8 to 8.8;
- causing a hemostatic agent to be adsorbed to a pretreated substrate;
- drying the substrate on which a hemostatic agent is adsorbed;
- primarily modifying the dried substrate using monochloro acetic acid (MCA) in the presence of a base;
- secondarily modifying the primarily modified substrate to be neutralized using an organic acid aqueous solution;
- washing the secondarily modified substrate by immersing and stirring the secondarily modified substrate in a solvent;
- and
- post-treating the washed substrate by adjusting the pH of the washed substrate to 7.35 to 7.45,
- wherein an organic acid aqueous solution used in the secondarily modifying contains citric acid and ascorbic acid in a weight ratio of 10:2 to 5.
Dependencies are inferred from the claim text.