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US 12,734,259 B2Granted
Compounds comprising a fibroblast activation protein ligand and use thereof
Assignee3B Pharmaceuticals GmbH
InventorsFrank Osterkamp, Dirk Zboralski, Eberhard Schneider, Christian Haase, Matthias Paschke, Aileen Höhne, Jan Ungewiss, Christiane Smerling, Ulrich Reineke, Anne Bredenbeck
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Abstract
The present invention is related to a compound comprising a cyclic peptide and a chelator, and its use.
Claims30
A compound, which is:
- or a pharmaceutically acceptable salt thereof, or a solvate thereof,
- wherein 68Ga is complexed to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator of the compound.
A compound:
- wherein 68Ga is complexed to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator of the compound.
A method of diagnosing a disease in a patient in need thereof, comprising administering to the patient in need thereof a diagnostically effective amount of a compound:
- wherein 68Ga is complexed to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator of the compound, and
- wherein the disease is breast cancer, non-small cell lung cancer, pancreatic cancer, or bladder cancer.
Dependencies are inferred from the claim text.