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US 12,734,252 B2Granted
Adeno-associated viral vector variants
AssigneeThe Children's Hospital of Philadelphia
InventorsBeverly Davidson, Yonghong Chen, Paul T. Ranum, Xueyuan Liu
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Abstract
Provided herein are targeting peptides and vectors containing a sequence that encodes the targeting peptides that deliver agents to specific substructures in the brain.
Claims19
A modified adeno-associated virus (AAV) capsid protein comprising a targeting peptide that targets a viral vector comprising the modified AAV capsid protein to a distinct organ or brain structure, wherein the targeting peptide comprises the amino acid sequence of SEQ ID NO:
- 21, wherein the modified AAV capsid protein is a modified AAV1 capsid protein having an amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO:
- 138 and the targeting peptide is inserted after residue 590 of the amino acid sequence of SEQ ID NO:
- 138.
Dependencies are inferred from the claim text.