Compositions and methods for targeted amplification of coagulation and phagocytosis
AssigneeCase Western Reserve University
InventorsAnirban Sen Gupta, Ujjal Didar Singh Sekhon
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Abstract
A nanoparticle and/or microparticle construct for therapeutic applications includes a plurality of targeting moieties that bind to target molecules of a cell, tissue, and/or disease site in a subject, phosphatidylserine phospholipids, and releasable cloaking agents configured to mask the phosphatidylserine phospholipids prior to binding of the target moieties to the target molecules and be released from the construct to expose the phosphatidylserine phospholipids upon binding of the target moieties to the target molecules.
Claims21
A composition, the composition comprising a plurality of nanoparticle and/or microparticle constructs, each construct having an outer portion that defines an outer surface of the construct, a plurality of targeting moieties and releasable cloaking agents that are linked to the outer portion and extend from the outer surface, and a plurality of phosphatidylserine phospholipids that extend from and/or define portions of the outer portion, wherein the targeting moieties are configured to specifically bind to target molecules of a cell, tissue, and/or disease site in a subject, and wherein the releasable cloaking agents are configured to mask the phosphatidylserine phospholipids prior to binding of the target moieties to the target molecules and be released from the construct to expose the phosphatidylserine phospholipids upon binding of the target moieties to the target molecules.
Dependencies are inferred from the claim text.