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US 12,734,246 B2Granted
Anti-transferrin receptor (TFR) antibody, encoding nucleic acid thereof and method of use thereof to deliver an oligonucleotide to a subject
AssigneeDyne Therapeutics, Inc.
InventorsRomesh R. Subramanian, Mohammed T. Qatanani, Timothy Weeden, Cody A. Desjardins, Brendan Quinn, John Najim
Life of this patent
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Abstract
Aspects of the disclosure relate to antibodies that bind to transferrin receptor (e.g., transferrin receptor 1) and complexes comprising the antibody covalently linked to a molecular payload. Methods of using the antibodies are also provided.
Claims64
An antibody that binds to human transferrin receptor (TfR), wherein the antibody comprises a heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:
- 76 and a light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:
- 75.
Dependencies are inferred from the claim text.