Treatment and/or diagnosis of a cancer type characterized by expressing zinc transporter ZIP4

A method of using a nanocarrier in the treatment and/or diagnosis of a cancer, the method comprising:

• functionalizing the nanocarrier with an affinity reagent,
• wherein the affinity reagent comprises a monoclonal antibody comprising:
• a light chain variable region (VL) comprising LCDR1, LCDR2, and LCDR3 polypeptides;
• and
• a heavy chain variable region (VH) comprising HCDR1, HCDR2, and HCDR3 polypeptides,
• wherein the HCDR1 comprises the sequence of SEQ ID NO:
• 4,
• wherein the HCDR2 comprises the sequence of SEQ ID NO:
• 5,
• wherein the HCDR3 comprises the sequence of SEQ ID NO:
• 6,
• wherein the LCDR1 comprises the sequence of SEQ ID NO:
• 9,
• wherein the LCDR2 comprises KVS,
• wherein the LCDR3 comprises the sequence of SEQ ID NO:
• 10;
• wherein the affinity reagent binds to an extracellular domain of Zinc transporter ZIP4,
• wherein the extracellular domain of ZIP4 comprises the sequence of SEQ ID NO:
• 1, and
• wherein the cancer expresses ZIP4, and
• administering the functionalized nanocarrier to a subject.