K562 universal antigen presenting cells and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsSonny O. T. Ang, Enli Liu, Elizabeth Shpall, Katy Rezvani
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Abstract
Provided herein are universal antigen presenting cells. Also provided herein are methods of expanding immune cells using the UAPCs and methods for the treatment of a disease, such as cancer, using the expanded immune cells.
Claims59
A K562 universal antigen presenting cell (UAPC) engineered to express (1) CD48, (2) membrane-bound interleukin-21 (mbIL-21), and (3) 41BB ligand (41BBL), wherein the K562 UAPC is essentially free of expression of endogenous HLA class I, II, or CD1d molecules, wherein the UAPC in co-culture with NK cells induces expansion of the NK cells.
Dependencies are inferred from the claim text.