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US 12,734,209 B2Granted
CD38 antibody drug conjugate
AssigneeOgory, Inc.
InventorsTong Zhu, Alisher Khasanov, Gang Chen, Katherine Fells, Heyue Zhou, John Dixon Gray
Life of this patent
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Abstract
There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a CD38 target conjugated at a Cys site in the hinge region of an IgG antibody. There is further disclosed a method for treating multiple myeloma comprising providing an effective amount of a CD38 ADC.
Claims1
A method for treating multiple myeloma comprising providing a therapeutically effective amount of an anti-CD38 antibody drug conjugate (ADC) composition, wherein the anti-CD38 ADC is
- and wherein Ab is an anti-CD38 IgG antibody comprising a heavy chain variable region comprising the sequence of SEQ ID NO. 1 and a light chain variable region comprising the sequence of SEQ ID NO. 2 or 3.
Dependencies are inferred from the claim text.