Methods and compositions for treating dysbiosis of oral microbiome

A method of treating or inhibiting a dysbiosis of oral microbiome of a subject in need thereof comprising administering a pharmaceutical composition comprising:

• (i) one or more polyphenols selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, and tetrahydrocurcumin;
• (ii) one or more high polarity compounds extracted from Curcuma longa using a solvent system that has a dielectric constant of greater than 25 or a relative polarity greater than 0.6, wherein the one or more high polarity compounds are selected from the group consisting of peptides, polysaccharides, and proteins;
• (iii) one or more non-polar compounds selected from the group consisting of terpenoids, ar-turmerone, α-turmerone, and β-turmerone;
• and
• (iv) one or more emulsifier, surfactant, or a combination thereof;
• wherein the dysbiosis of the oral microbiome is determined by a change in a relative abundance of bacterial phyla in comparison to the subject's baseline composition of bacterial phyla prior to administration.