Complex composition for preventing or treating hearing loss including sarpogrelate and Vaccinium myrtillus extract as active ingredients
AssigneeImdpharm Inc.
InventorsSook Choi, Sang Kyu Shin
Life of this patent
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Abstract
The present invention relates to a complex composition for preventing or treating hearing loss, including sarpogrelate and a Vaccinium myrtillus extract as active ingredients, wherein the complex composition has been confirmed to effectively inhibit hair cell death by reactive oxygen species generated by hydrogen peroxide, in a small dose, and exhibit an excellent protective effect on zebrafish auditory hair cells, and therefore, the complex composition can be effectively used as a drug or health food for preventing or treating hearing loss.
Claims4
A method of preventing or treating hearing loss in a subject in need thereof, comprising:
- administering a pharmaceutical composition comprising sarpogrelate and a Vaccinium myrtillus extract in a weight ratio of 1:2 to 1:8 as active ingredients to the subject,
- wherein the pharmaceutical composition inhibits apoptosis of auditory cells and increases the number of hair cells, compared to single administration of the Vaccinium myrtillus extract or sarpogrelate.
A method of preventing or ameliorating hearing loss in a subject in need thereof, comprising:
- administering a health food comprising sarpogrelate and a Vaccinium myrtillus extract in a weight ratio of 1:2 to 1:8 as active ingredients to the subject,
- wherein the health food inhibits apoptosis of auditory cells and increases the number of hair cells, compared to single administration of the Vaccinium myrtillus extract or sarpogrelate.
Dependencies are inferred from the claim text.