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US 12,734,194 B2Granted
Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents
AssigneeChildren's Medical Center Corporation
InventorsJames D. McCully, Pedro J. del Nido
Life of this patent
Estimating the term…
Abstract
The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating or preventing disorders or damage associated with ischemia-reperfusion injury (IRI) using such compositions.
Claims16
A method of reducing risk of ischemia-reperfusion injury (IRI) in a subject, comprising:
- identifying a subject at risk for IRI;
- and
- administering to the subject a therapeutically effective amount of a composition comprising isolated mitochondria and/or a combined mitochondrial agent, wherein the composition is administered to the subject prior to ischemia or an ischemic event.
A method of preventing or treating cell damage, tissue damage, and/or organ damage associated with IRI in a subject, comprising:
- identifying the subject at risk for, or having, cell damage, tissue damage, and/or organ damage associated with IRI;
- and
- administering to the subject a therapeutically effective amount of a composition comprising isolated mitochondria and/or a combined mitochondrial agent, wherein the composition is administered prior to ischemia or an ischemic event.
Dependencies are inferred from the claim text.