Ammonium chloride formulation to support human natural defense against viruses
AssigneeNikolaos Tsirikos-Karapanos
InventorsNikolaos Tsirikos-Karapanos, Nikolaos Drakoulis
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Abstract
Formulations and uses thereof are provided for supporting human natural defense against viral infections as well as providing treatment for viral infections susceptible to a lysosomotropic agent. Administration of a lysosomotropic agent, such as ammonium chloride (NH4Cl), can militate against the uncoating of viruses within the lysosome of an infected cell and thereby minimize infection by viruses whose replication cycle relies upon an uncoating step in such a manner.
Claims19
A method of treating a clinical manifestation of infection by a virus in a subject in need thereof, the method comprising:
- administering a formulation to the subject, the formulation including a lysosomotropic agent, wherein the lysosomotropic agent includes ammonium chloride, whereby the lysosomotropic agent interferes with viral uncoating, provides a viral-static effect, and allows immunological mechanisms of the subject to produce antibodies against the virus, wherein the virus includes SARS-CoV-2 virus;
- monitoring the subject for at least one of alkalosis and acidosis, wherein the monitoring includes measuring a blood pH of the subject;
- selectively adjusting the administering of the formulation to the subject based on the monitoring so that the subject is not exhibiting alkalosis and is not exhibiting acidosis, wherein the selectively adjusting includes adjusting the administering of the formulation to the subject until the blood pH of the subject is between about 7.35 and about 7.45;
- and
- continuing the administration of the formulation to the subject until an antibody to the virus is detected in the subject,
- wherein:
- the formulation includes an enteric coating configured for oral administration;
- or
- the formulation is configured for sustained release of the lysosomotropic agent to the subject's skin.
A method of treating a clinical manifestation of infection by a virus in a subject in need thereof, the method comprising:
- administering a sustained release formulation to the subject, the sustained release formulation including a lysosomotropic agent including ammonium chloride, whereby the lysosomotropic agent interferes with viral uncoating, provides a viral-static effect, and allows immunological mechanisms of the subject to produce antibodies against the virus, wherein the virus includes SARS-CoV-2 virus;
- monitoring the subject for at least one of alkalosis and acidosis, wherein the monitoring includes measuring a blood pH of the subject;
- selectively adjusting the administering of the formulation to the subject based on the monitoring so that the subject is not exhibiting alkalosis and is not exhibiting acidosis, wherein the selectively adjusting includes adjusting the administering of the formulation to the subject until the blood pH of the subject is between about 7.35 and about 7.45;
- and
- continuing the administration of the formulation to the subject until an antibody to the virus is detected in the subject.
A method of treating a clinical manifestation of infection by a virus in a subject in need thereof, the method comprising:
- administering a formulation to the subject, the formulation comprising ammonium chloride, at least one excipient, and an enteric coating configured for oral administration;
- monitoring the subject for at least one of alkalosis and acidosis, wherein the monitoring includes measuring a blood pH of the subject;
- selectively adjusting the administering of the formulation to the subject based on the monitoring so that the subject is not exhibiting alkalosis and is not exhibiting acidosis, wherein the selectively adjusting includes adjusting the administering of the formulation to the subject until the blood pH of the subject is between about 7.35 and about 7.45;
- and
- continuing the administration of the formulation to the subject until an antibody to the virus is detected in the subject.
Dependencies are inferred from the claim text.