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US 12,734,189 B2Granted
Methods for enhancing cytotoxic cancer therapy through modulation of purine biosynthesis pathways
AssigneeNorthwestern University
InventorsAtique U. Ahmed, Jack M. Shireman, Cheol H. Park
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Abstract
Disclosed are methods and compositions for treating proliferative cell diseases and disorders such as cancers. Particularly disclosed are methods and composition for treating cancers such as glioblastoma by administering a therapeutic agent that alters the pathways used for purine biosynthesis by inhibiting the biological activity of ARL13B and/or IMPDH proteins in conjunction with additional therapeutic agents such as alkylating agents.
Claims8
A method of treating an ARL13B-mediated proliferative cell disease or disorder in a subject in need thereof, the method comprising:
- (a) administering to the subject a therapeutic agent that down-regulates expression of ARL13B or that inhibits biological activity of ARL13B;
- and
- (b) administering to the subject an alkylating agent,
- wherein the ARL13B-mediated proliferative cell disease or disorder is selected from the group consisting of mesenchymal subtype glioblastoma, classical subtype glioblastoma, and proneural subtype glioblastoma;
- wherein the subject is administered an effective amount of the therapeutic agent in step (a) to synergize effectiveness of the administered alkylating agent.
2 more elements
Dependencies are inferred from the claim text.