Methods of treating ischemic stroke at risk for cerebral or cerebellar edema
AssigneeRemedy Pharmaceuticals, Inc.
InventorsSven Martin Jacobson, Thomas W. Macallister
Life of this patent
Estimating the term…
Abstract
The invention relates to the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy. In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, patients have a lesion volume of less than 140 cm3 or less than 125 cm3 as measured by MRI DWI or CTP. The patient may have suffered a wake-up stroke. Some embodiments involve treating patients who also undergo decompressive therapy.
Claims26
A method of treating a patient diagnosed with a large hemispheric infarction, wherein the patient has a lesion volume of >50 cm3 and <125 cm3, and a National Institutes of Health stroke score system (NIHSS)≤20, or an Alberta Stroke Program Early CT Score (ASPECTS) of ≤5, comprising administering to the patient via continuous infusion an infusion solution and a reconstituted formulation comprising a SUR1-TRPM4 channel inhibitor and a buffering agent, wherein the reconstituted formulation is reconstituted from a lyophilized powder comprising the SUR1-TRPM4 channel inhibitor using a diluent such that the reconstituted formulation has a pH outside of the buffering capacity of the buffering agent.
Dependencies are inferred from the claim text.