Progesterone formulation to trigger ovulation and provide luteal phase support
AssigneesAugusta University Research Institute, Inc., Vitrovita LLC
InventorsMichael Peter Diamond, Dmitri Dozortsev
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Abstract
Disclosed herein are compositions and methods for ovulation induction in females in need thereof. Current methods for inducing ovulation have unpleasant side effects and are expensive. The disclosed compositions and methods are safe, efficacious, and inexpensive. An exemplary method of inducing ovulation includes steps of monitoring ovarian follicle development and size during the follicular phase of the menstrual cycle; and administering to the subject a pharmaceutical composition including progesterone or bioidentical progesterone in an amount effective to increase the plasma concentration of progesterone to between about 0.1 ng/ml to about 1 ng/ml when the follicle reaches a size of at least 15 mm.
Claims23
A method of triggering ovulation in a subject in need thereof comprising,
- (i) monitoring ovarian follicle development and size during the follicular phase of the menstrual cycle in the subject;
- and
- (ii) when the follicle reaches a size of at least 15 mm, administering to the subject a pharmaceutical composition comprising progesterone, bioidentical progesterone, or progestin in an amount effective to increase the plasma concentration of progesterone in the subject to a level of about 0.1 ng/ml-100 ng/ml,
- wherein the subject is a human.
Dependencies are inferred from the claim text.