Preparation for ethinylestradiol-cyclodextrin complex and use thereof
AssigneeNational Research Institute for Family Planning
InventorsJuan Xu, Lifeng Ning, Bin He
Life of this patent
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Abstract
Disclosed are preparation for an ethinylestradiol-cyclodextrin complex and use thereof. The ethinylestradiol-cyclodextrin complex utilizes the properties of cyclodextrin that the inner cavity is hydrophobic and the outer surface is hydrophilic to increase the water solubility of the ethinylestradiol-cyclodextrin complex that is also an ethinylestradiol drug, so that the solubility of ethinylestradiol is greatly increased and the bioavailability of water-insoluble ethinylestradiol is improved, thereby providing the possibility for changing the administration mode and homogeneous injection of ethinylestradiol.
Claims20
A pharmaceutical composition, comprising ethinylestradiol and cyclodextrin, wherein the ethinylestradiol and the cyclodextrin interact to form a clathrate, and the cyclodextrin is β-cyclodextrin or a derivative thereof, wherein β-cyclodextrin is selected from ethylenediamine-β-cyclodextrin, diethylenetriamine-β-cyclodextrin, triethylenetetramine-β-cyclodextrin, tetraethylenepentamine-β-cyclodextrin, and hydroxypropyl-β-cyclodextrin.
Dependencies are inferred from the claim text.