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US 12,734,177 B2Granted
Macrocyclic derivative and use thereof
AssigneeGuangzhou Joyo Pharmatech Co., Ltd
InventorsYang Zhang, Kai Zhou, Fen Jiang, Li Zhang, Xiao Liu, Zheng Wang, Kevin X. Chen, Jian Li, Shuhui Chen
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Abstract
The present disclosure discloses a class of macrocyclic derivatives, and specifically discloses a compound shown in formula (VI), a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.
Claims9
A compound with the following formula:
- wherein:
- R1 is selected from H and C1-4 alkyl;
- and
- wherein the compound has an enantiomeric purity of at least about 90%.
1 more element
A compound with the following formula:
- wherein:
- R1 is selected from H and C1-4 alkyl;
- and
- R2 and R3 are independently selected from a nitrogen protecting group selected from the group consisting of acetyl, trichloroacetyl, trifluoroacetyl, tert-butoxycarbonyl (Boc), benzyloxycarbonyl (Cbz), 9-fluorenylmethyloxycarbonyl (Fmoc), benzyl (Bn), trityl (Tr), 1,1-bis-(4′-methoxyphenyl)methyl, trimethylsilyl (TMS), and tert-butyldimethylsilyl (TBS).
1 more element
Dependencies are inferred from the claim text.