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US 12,734,172 B2Granted
Method and composition for treating pain
AssigneeAcademia Sinica
InventorsChin-Cheng Chen, Chin-Hsien Hung
Life of this patent
Estimating the term…
Abstract
Provided are methods and compositions for prevention or treatment of pain, e.g., stress-related pain. Also provided is a method for producing a non-human animal model for pain, the non-human animal model produced therefrom, and a method of screening an agent pharmaceutically active in prevention or treatment of pain using such non-human animal model.
Claims5
A method for treating pain or a pain disorder comprising administering to a subject in need thereof an effective amount of an inhibitor of lysophosphatidylcholine (LPC) generation,
- wherein the pain or the pain disorder includes fibromyalgia, primary headache, migraine, tension type headache, restless leg syndrome (RLS), muscular discomfort, limb soreness, lower back pain, cancer pain, arthritis pain or psychogenic pain, or the pain is caused by an irritable bowel syndrome, a bladder pain syndrome or a temporomandibular disorder;
- and
- wherein the inhibitor of LPC generation is:
- a pyrimidine-4-one derivative selected from N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[4′-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide
- 2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide
- an antioxidant selected from the group consisting of ascorbic acid, Na-ascorbate, L-cysteine, N-acetylcysteine (NAC), glutathione (GSH), Na2-EDTA, Na2-EDTA-Ca, and sodium bisulfite.
3 more elements
Dependencies are inferred from the claim text.