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US 12,734,162 B2Granted
SerpinB3 inhibitor piperidinpropionic acid for tumor treatment
AssigneeUniversita' Degli Studi Di Padova
InventorsPatrizia Pontisso, Alessandra Biasiolo, Andrea Martini, Santina Quarta, Mariagrazia Ruvoletto, Cristian Turato, Gianmarco Villano
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Abstract
The invention concerns the use of 1-Piperidinpropionic acid or salts thereof, for the treatment of tumors that express SerpinB3.
Claims5
A method for treating a chemoresistant tumor expressing SerpinB3, said method comprising
- treating said chemoresistant tumor with between 1-100 ng/ml of 1-Piperidinpropionic acid (PPA) or salts thereof, wherein said chemoresistant tumor is resistant to 10 μM of a chemotherapeutic drug selected from the group consisting of cisplatin, sorafenib, 5-fluorouracil or wherein said chemoresistant tumor is resistant to immune system surveillance, and wherein said tumor is selected from the group consisting of a liver tumor and glioblastoma.
Dependencies are inferred from the claim text.