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US 12,734,155 B2Granted
Methods and compositions for treating glucocorticoid excess
AssigneeSparrow Pharmaceuticals, Inc.
InventorDavid A. Katz
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Abstract
The disclosure provides a method of treatment for glucocorticoid excess in a patient in need thereof, comprising administering to the patient a pseudo-irreversible HSD-1 inhibitor.
Claims29
A method for treating diabetes in a human patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
- wherein the therapeutically effective amount of the compound, or the pharmaceutically acceptable salt thereof, is about 0.2 mg to about 40 mg daily,
- wherein the treatment decreases the patient's hemoglobin A1c (HbA1c), and
- wherein the compound does not show tachyphylaxis for HSD-1 inhibition in human adipose tissue.
Dependencies are inferred from the claim text.