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US 12,734,152 B2Granted
Solid state forms of Nirogacestat salts
AssigneeAssia Chemical Industries Ltd.
InventorsAnantha Rajmohan Muthusamy, Amit Singh
Life of this patent
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Abstract
The present disclosure encompasses solid state forms of Nirogacestat salts, in embodiments crystalline polymorphs of Nirogacestat salts, processes for preparation thereof, and pharmaceutical compositions thereof.
Claims23
A crystalline form of Nirogacestat dihydrobromide salt designated Form NT1, which is characterized by data selected from one or more of the following:
- (a) an X-ray powder diffraction pattern substantially as depicted in FIG. 6;
- (b) an X-ray powder diffraction pattern having peaks at 10.9, 21.2, 24.5, 26.0 and 27.4 degrees 2-theta±0.2 degrees 2-theta;
- (c) a solid state 13C NMR spectrum with peaks at 17.0, 27.9, 55.4, 115.3, 133.3 and 165.6 ppm±0.2 ppm;
- (d) a solid state 13C NMR spectrum having the following chemical shift absolute differences from a peak at 57.4 ppm±2 ppm of 40.4, 29.5, 2.0, 57.9, 75.9 and 108.2 ppm±0.1 ppm;
- (e) a solid state 13C NMR spectrum substantially as depicted in any of FIG. 7, 8 or 9;
- and combinations of these data.
3 more elements
A crystalline form of Nirogacestat hydrobromide salt designated Form NHBr1, which is characterized by an X-ray powder diffraction pattern having peaks at 6.5, 11.5, 17.9, 20.6 and 27.1 degrees 2-theta±0.2 degrees 2-theta;
- or an X-ray powder diffraction pattern substantially as depicted in FIG. 1.
Dependencies are inferred from the claim text.