Methods for treating bone and neuropathic pain with capsaicin
OwnerJames Ciulloinventor
Life of this patent
Estimating the term…
Abstract
A transdermal patch and methods for delivering capsaicin to reduce pain are disclosed. The patch comprises capsaicin and a release liner, and may include permeation-enhancing agents. High-dose patches are configured for short-duration application to produce localized defunctionalization of TRPV1-expressing nociceptive terminals, while low-dose patches provide sustained delivery for extended wear. Application to affected dermatomes or regions of sensory loss reduces pain associated with post-herpetic neuralgia, post-surgical neuropathic pain, diabetic neuropathy, radiculopathy, nerve trauma, and bone-related pain states including microarchitectural bone changes. The disclosure further relates to capsaicin compositions, patch structures, and methods of manufacture and use.
Claims9
A method of treating post-herpetic neuralgia (PHN) pain in a subject, comprising:
- applying a patch to a skin surface, the patch comprising about 8 wt % capsaicin, wherein the PHN comprises partial or complete deafferentation of a sensory pathway.
A method of treating post-surgical neuropathic pain in a subject, comprising:
- applying a patch to a skin surface, the patch comprising about 8 wt % capsaicin, wherein the post-surgical neuropathic pain comprises central neuropathic pain.
A method for treating chronic back pain in a subject without a spinal cord injury, comprising:
- applying a patch to a skin surface, the patch comprising capsaicin.
Dependencies are inferred from the claim text.