Epinephrine fine particles and methods for use thereof
AssigneeNova Southeastern University
InventorsMutasem Rawas-Qalaji, Ousama Rachid, Keith Simons, Estelle Simons
Life of this patent
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Abstract
Compositions include epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.
Claims18
A method for increasing absorption of epinephrine in a subject having a condition responsive to treatment with epinephrine, the method comprising:
- providing a pharmaceutical composition formulated for buccal or sublingual administration including epinephrine bitartrate fine particles ranging in size from about 2.5 μm to about 100 μm and at least one inactive and non-toxic substance, the epinephrine bitartrate fine particles formed by homogenizing raw epinephrine bitartrate particles;
- and
- administering the pharmaceutical composition to the subject, thereby increasing the absorption of epinephrine in the subject having the condition responsive to treatment with epinephrine;
- wherein the epinephrine bitartrate fine particles formed by homogenizing raw epinephrine bitartrate particles have a spherical shape, the spherical shape formed when raw epinephrine bitartrate particles having a rectangular shape undergo a morphological change during homogenization to form the epinephrine bitartrate fine particles of the pharmaceutical composition.
A method for increasing absorption of epinephrine in a subject having a condition responsive to treatment with epinephrine, the method comprising:
- providing a pharmaceutical composition formulated for buccal or sublingual administration including epinephrine bitartrate fine particles ranging in size from about 2.5 μm to about 100 μm and at least one inactive and non-toxic substance, the epinephrine bitartrate fine particles consisting of epinephrine bitartrate fine particles formed by homogenizing raw epinephrine bitartrate particles;
- and
- administering the pharmaceutical composition to the subject, thereby increasing the absorption of epinephrine in the subject having the condition responsive to epinephrine;
- wherein the epinephrine bitartrate fine particles formed by homogenizing raw epinephrine bitartrate particles have a spherical shape, the spherical shape formed when raw epinephrine bitartrate particles having a rectangular shape undergo a morphological change during homogenization to form the epinephrine bitartrate fine particles of the pharmaceutical composition.
Dependencies are inferred from the claim text.