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US 12,734,130 B2Granted
Pharmaceutical composition and method for enhancing solubility of poorly soluble active pharmaceutical ingredients
AssigneeMerck Patent GmbH
InventorsThomas Kipping, Finn Bauer, Nicole Di Gallo, Anja-Nadine Knuettel, Alessandro Giuseppe Elia
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Abstract
The present invention relates to pharmaceutical compositions using polymers as an excipient. Particularly, the invention relates to a pharmaceutical composition comprising polyvinyl alcohol which is suitable to enhance solubility of poorly soluble active pharmaceutical ingredients in aqueous media. The present invention also relates to a method for enhancing solubility of poorly soluble active pharmaceutical ingredients.
Claims9
A pharmaceutical composition comprising:
- an amorphous solid dispersion of at least one weakly basic active pharmaceutical ingredient in a polymer matrix, wherein the polymer is polyvinyl alcohol having a hydrolysis degree of 80%-83%, and a viscosity of a 4% solution at 20° C. of 3 mPas.
Dependencies are inferred from the claim text.