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AssigneesNew York University, Regenosine, Inc.
InventorsSiddhesh R. Angle, Carmen Corciulo, Bruce N. Cronstein, Jonathan Kaufman
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Provided are liposomes that encapsulate adenosine. The liposomes may be formed from sphingomyelin or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG, and DMPC. The liposomes encapsulating adenosine may be used to induce cartilage regeneration, treat osteoarthritis, alleviate joint pain, and/or slow, arrest, and/or reverse progressive structural tissue damage associated with osteoarthritis or treat osteoarthritis, rheumatoid arthritis, acute gouty arthritis, and/or synovitis. The liposomes may release adenosine for up to two weeks.
An injectable formulation suitable for intra-articular injection comprising saline and liposomes comprising one or more lamellae, wherein the liposome lamellae consist of 70 to 99.9% by mass sphingomyelin, a sterol, 1,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG), and optionally 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and
Dependencies are inferred from the claim text.