Cationic material for tooth desensitization, preparation method therefor, and application thereof

A method of using a cationic material for dental desensitization in oral materials to reduce action potential of the trunk of mandibular nerve, comprising applying the cationic material to a surface of a tooth or tooth coverings of a subject in need,

• wherein the cationic material comprises a polyquaternium-10 hydrogel, the polyquaternium-10 has a molecular weight of 100 to 5000 kDa and a charge density of 0.0001 to 0.002 eq/g and a nitrogen content of 0.5 to 2.5 wt %, and the mass concentration of the polyquaternium-10 in the hydrogel is 0.1% to 10%,
• wherein the polyquaternium-10 hydrogel is prepared according to a method comprising the following steps:
• step (1) dispersing hydroxyethyl cellulose in deionized water, stirring and dissolving uniformly, adding sodium hydroxide and 2,3-epoxypropyltrimethylammonium chloride respectively, and letting them react to obtain a reaction mixture;
• step (2) neutralizing the reaction mixture obtained in the step (1) with hydrochloric acid, and then performing dialysis and freeze-drying to obtain the polyquaternium-10;
• step (3) preparing the polyquaternium-10 obtained in the step (2) into the polyquaternium-10 hydrogel with the mass concentration of 0.1% to 10%.