System and method for mode switching

A method of automatically changing modes in a diabetes management system, comprising:

• operating a monitoring device in a non-therapeutic mode during which glucose of a user is monitored and glucose information is provided to the user, but the monitored glucose is not used to base insulin dosing decisions for the user;
• while operating the monitoring device in the non-therapeutic mode, operating the monitoring device in a first calibration mode;
• performing a first transition to operate the monitoring device in a therapeutic mode during which glucose of the user is monitored and the monitored glucose is used to base insulin dosing decisions for the user, wherein criteria for performing the first transition are at least partially based on a glucose range of a current glucose value of the user and a time-of-day;
• and
• responsive to the first transition, performing a second transition to operate the monitoring device in a second calibration mode, wherein the first calibration mode comprises one of a user-dependent calibration mode or a factory calibration mode and wherein the second calibration mode comprises a different one of the user-dependent calibration mode or the factory calibration mode.