Method for classifying an allergic patient as eligible to allergen immunotherapy

A method of treating a patient allergic to an antigen comprising:

• (i) classifying said allergic patient as eligible to allergen immunotherapy, said method comprising screening the T cell reactivity of said patient to an allergen, said screening comprising the following steps:
• a) contacting with an allergen an isolated biological sample of the patient containing T cells,
• b) measuring T cell reactivity to said allergen,
• c) calculating a stimulation index as the ratio of the T cell reactivity measured in step b) on T cell reactivity of the isolated biological sample of the patient containing T cells unstimulated by the allergen,
• d) classifying said patient as being eligible to treatment with a composition comprising said allergen if the stimulation index is equal or above a threshold value;
• and
• (iia) administering to the patient a composition comprising the allergen if the patient is classified as being eligible to treatment with a composition comprising said allergen, and
• (iib) if the patient is not classified as eligible to treatment with a composition comprising said allergen:
• a) determining the patient's sensitivity to individual allergenic proteins of the allergen;
• b) spiking the allergen with the allergenic protein(s) to which the patient is sensitized;
• and
• c) administering to the patient the spiked allergen.