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US 12,730,107 B2Granted
Reagent composition for immunophenotyping of B lymphoblastic leukemia/lymphoma and use thereof
OwnerYanrong Liu, Yazhe Wanginventors
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OwnerYanrong Liu, Yazhe Wanginventors
Estimating the term…
Provided is a reagent composition for immunophenotyping and MRD monitoring of B lymphoblastic leukemia/lymphoma (B-ALL/LBL). The reagent composition includes a 20-antibody combination. In the present disclosure, the antibody combination, the fluorescent labeling combination for the corresponding antibody, and the result interpretation methods are optimized. It only needs to use 20 kinds of antibodies in a single tube of cells for one sample loading, allowing for comprehensively and efficiently performing subtype typing on B lymphoblastic leukemia/lymphoma. In addition, it enables to predict part of recurrent genetically abnormal B-ALL/LBL and has high sensitivity and specificity for the diagnosis of the subtype of BCR/ABL1 gene. Meanwhile, it enables to determine the leukemia-related immunophenotype (LAIP) for minimal residual disease (MRD) monitoring after treatment by using the combination and used for MRD monitoring and CAR-T post-treatment monitoring.
A reagent composition for immunophenotyping and/or MRD monitoring of B lymphoblastic leukemia/lymphoma, wherein the reagent composition consists of a combination of antibodies:
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