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AssigneeThe Regents of the University of Micigan
InventorsLonnie D. Shea, Robert S. Oakes, Aaron Morris, Kevin Hughes
Estimating the term…
Provided herein are methods of monitoring progression, regression, or stage of an AID in a subject, measuring a level of expression of a gene, an RNA, or a protein, or a combination thereof, in a sample obtained from a niche at the implantation site of a synthetic scaffold in the subject at a first time point and at a second time point, wherein the expression level measured at the first time point is compared to the expression level measured at the second time point, wherein the difference in the level of expression at the second time point relative to the level of expression at the first time point is indicative of progression, regression, or stage of the autoimmune disease. Related methods of detecting an AID, determining treatment for a subject with an AID, determining efficacy of an AID treatment, or treating an AID, are further provided.
A method comprising measuring a level of expression of a gene in a sample obtained from a niche at an implantation site of a synthetic scaffold in a mammalian subject, wherein the synthetic scaffold comprises poly(e-caprolactone) (PCL), poly(lactide-co-glycolide) (PLG), poly(ethylene glycol) (PEG), and/or alginate, wherein the mammalian subject has or is suspected of having an autoimmune disease selected from multiple sclerosis and diabetes, and wherein:
Dependencies are inferred from the claim text.