US 12,730,091 B2 · Method and systems for analyzing ions using differential mobility spectrometry and ion guide comprising additional auxiliary electrodes

Abstract

Methods and systems for performing differential mobility spectrometry-mass spectrometry (DMS-MIS) are provided herein. In various aspects, methods and systems described may be effective to improve the performance of a differential mobility spectrometry device and a MS device operating in tandem relative to conventional systems for DMS-MS. In certain aspects, methods and systems in accordance with the present teachings utilize an ion guide which comprises a multipole rod set and a plurality of auxiliary electrodes to which a DC voltage is applied during transmission of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide to accelerate the ions toward the outlet end of the ion guide. This may significantly reduce a pause duration between the application of different compensation voltage values without substantially increasing the likelihood of contamination or cross-talk between groups of ions transmitted by the differential mobility spectrometry device at each compensation voltage value.

Claims20

Dependent claims

A method for analyzing ions, comprising:

receiving in an ion guide, a first plurality of ions transmitted from a differential mobility spectrometry device while having a first combination of separation voltage and compensation voltage applied thereto, wherein the ion guide comprises a multipole rod set extending along a longitudinal axis from an inlet end to an outlet end and a plurality of auxiliary electrodes;
receiving in the ion guide, a second plurality of ions transmitted by the differential mobility spectrometry device while having a second combination of separation voltage and compensation voltage applied thereto, wherein at least one of the separation voltage and compensation voltage in the second combination differs from the separation voltage and compensation voltage in the first combination;
and
while transmitting the first and second plurality of ions through the ion guide, applying a DC voltage to the auxiliary electrodes so as to generate an axial electric field along a longitudinal axis of the ion guide.

1 more element

A mass spectrometry system, comprising:

a differential mobility spectrometry device, wherein when activated, the differential mobility spectrometry device is configured to separate ions based on their differential mobilities;
an ion guide configured to receive ions from the differential mobility spectrometry device, wherein the ion guide comprises:
a multipole rod set extending along a longitudinal axis from an inlet end to an outlet end;
and
a plurality of auxiliary electrodes;
and
a control system operatively coupled to the differential mobility spectrometry device and the ion guide, the control system configured to:
cause a first combination of separation voltage and compensation voltage to be applied to the differential mobility spectrometry device so as to transmit a first plurality of ions;
cause a second combination of separation voltage and compensation voltage to be applied to the differential mobility spectrometry device so as to transmit a second plurality of ions, wherein at least one of the separation voltage and compensation voltage in the second combination differs from the separation voltage and compensation voltage in the first combination;
and
cause a DC voltage to be applied to the auxiliary electrodes while transmitting the first and second plurality of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide.

8 more elements

Dependencies are inferred from the claim text.

Method and systems for analyzing ions using differential mobility spectrometry and ion guide comprising additional auxiliary electrodes

Life of this patent

Method and systems for analyzing ions using differential mobility spectrometry and ion guide comprising additional auxiliary electrodes

Life of this patent

Abstract

Claims20