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US 12,730,072 B1Granted
Systems and methods using photonic structure substrates
AssigneeUltima Genomics, Inc.
InventorOsip Schwartz
Life of this patent
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Abstract
A photonic structure on a substrate, when illuminated with one of multiple predetermined illumination conditions, may transform the illumination light beam(s) to provide optical excitation to a predetermined subset of locations on a substrate. Signals collected from different subsets of locations on the substrate may be processed to yield a high-resolution optical readout.
Claims20
A substrate, comprising:
- a plurality of predetermined locations in or on a surface of the substrate, the predetermined locations configured to immobilize a plurality of analytes;
- and
- a photonic structure that is configured to transform one or more illumination light beams of an illumination condition impinging thereon to provide excitation to a subset of the plurality of predetermined locations, whereby:
- at a first illumination condition, a first subset of the plurality of predetermined locations is provided with a first range of excitation intensities that is higher than a predetermined excitation intensity threshold, wherein a remainder of the plurality of predetermined locations excluding the first subset is provided with a second range of excitation intensities lower than the predetermined excitation intensity threshold, and
- at a second illumination condition, a second subset of the plurality of predetermined locations is provided with the first range of excitation intensities, wherein a remainder of the plurality of predetermined locations excluding the second subset is provided with the second range of excitation intensities;
- and
- wherein the first illumination condition differs from the second illumination condition, and wherein the first subset differs from the second subset.
4 more elements
Dependencies are inferred from the claim text.