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US 12,730,060 B2Granted
Systems and methods for photoacoustic microscopy
AssigneeDuke University
InventorJunjie Yao
Life of this patent
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Abstract
Systems and methods for producing an ultrafast functional photoacoustic microscopy system are disclosed herein. Such systems are configured to enable the imaging of microvasculature and functional dynamics of tissue samples with a broad field of view and high spatial resolution. According to several disclosed embodiments, a combination of a Raman path and a polygon scanner in water immersion and air immersion environments enables rapid imaging of target materials.
Claims20
A photoacoustic microscopy system comprising:
- a first dichroic reflecting surface;
- a second dichroic reflecting surface;
- a Raman path in optical communication with each of the first and second dichroic reflecting surfaces, the Raman path including:
- a Raman shifter configured to receive a first portion of a laser from the first dichroic reflecting surface and shift a wavelength of the first portion;
- and
- an optical delay line configured to receive a second portion of the laser from the first dichroic reflecting surface and delay the second portion from being received by the second dichroic reflecting surface;
- and
- a scanner assembly in optical communication with the second dichroic reflecting surface such that it receives both the first portion of the laser and the second portion of the laser from the second dichroic reflecting surface, the scanner assembly including a polygon scanner configured to direct the received first and second portions to a target site.
5 more elements
A photoacoustic microscopy system comprising:
- a Raman path having a Raman shifter configured to receive a first portion of a laser and shift a wavelength of the first portion and an optical delay line configured to receive a second portion of the laser and delay the second portion from being received at a location at which the first portion is received after its wavelength has been shifted;
- a scanner assembly in optical communication with the Raman path such that the scanner assembly receives the first and second portions of the laser, the scanner assembly including a polygon scanner immersed in fluid.
A photoacoustic microscopy system comprising:
- a Raman path having a Raman shifter configured to receive a first portion of a laser and shift a wavelength of the first portion and an optical delay line configured to receive a second portion of the laser and delay the second portion from being received at a location at which the first portion is received after its wavelength has been shifted;
- a scanner assembly in optical communication with the Raman path such that the scanner assembly receives the first and second portions of the laser, the scanner assembly including a cylindrically-focused ultrasound transducer and an air-operated polygon scanner, the air-operated polygon scanner being configured to focus an excitation light along a focal line of the cylindrically-focused ultrasound transducer, and the cylindrically-focused ultrasound transducer being mounted within a water tank, between an imaging plane of the photoacoustic microscopy system and the air-operated polygon scanner.
Dependencies are inferred from the claim text.