Monitoring vial conditions during a lyophilization process

A system for facilitating real-time monitoring of conditions within a vial during a lyophilization process occurring within a lyophilization chamber, the system comprising:

• the lyophilization chamber configured to hold the vial;
• a temperature sensor configured to measure a temperature within the lyophilization chamber and external to the vial;
• a pressure sensor configured to measure a pressure within the lyophilization chamber and external to the vial;
• and
• a computing system configured to
• for each time interval of a plurality of time intervals during a lyophilization process occurring within the lyophilization chamber, obtain (i) a current value of the temperature within the lyophilization chamber from the temperature sensor, and (ii) a current value of the pressure within the lyophilization chamber from the pressure sensor, and
• after each time interval of the plurality of time intervals,
• determine current values of one or more conditions within the vial, at least by (i) applying the current value of the temperature and the pressure within the lyophilization chamber as inputs to a heat and mass transfer balance model, and (ii) solving for a current value of a temperature within the vial,
• predict one or more future values of the one or more conditions within the vial corresponding to one or more future time intervals, and
• one or both of
• cause a display device to display the current and/or predicted future values of the one or more conditions within the vial to a user, and
• control, based on the current and/or predicted future values of the one or more conditions within the vial, (i) the temperature within the lyophilization chamber and/or (ii) the pressure within the lyophilization chamber.

One or more non-transitory computer-readable media storing instructions for facilitating real-time monitoring of conditions within a vial during a lyophilization process occurring within a lyophilization chamber that, when executed by one or more processors, cause the one or more processors to:

• for each time interval of a plurality of time intervals during the lyophilization process, determine (i) a current value of a temperature within the lyophilization chamber and external to the vial using a temperature sensor, and (ii) a current value of a pressure within the lyophilization chamber and external to the vial using a pressure sensor;
• and
• after each time interval of the plurality of time intervals,
• determine current values of one or more conditions within the vial, at least by (i) applying the current values of the temperature and the pressure within the lyophilization chamber as inputs to a heat and mass transfer balance model, and (ii) solving for a current value of a temperature within the vial,
• predict one or more future values of the one or more conditions within the vial corresponding to one or more future time intervals, and
• one or both of
• cause a display device to display the current and/or predicted future values of the one or more conditions within the vial to a user, and
• control, based on the current and/or predicted future values of the one or more conditions within the vial, (i) the temperature within the lyophilization chamber and/or (ii) the pressure within the lyophilization chamber.