Immune enhancers
AssigneeDeutsches Krebsforschungszentrum
InventorsNikolaus Dietlein, Hans-Reimer Rodewald
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Abstract
The present invention relates to an inhibitor of ubiquitin-specific peptidase 22 (Usp22 inhibitor) for use in activation of an immune response in a subject and to a kit comprising said Usp22 inhibitor. The present invention further relates to methods for identifying a subject susceptible to treatment of disease by administration of a Usp22 inhibitor and for identifying a compound for activation of an immune response in a subject, as well as to a medicament for treating and/or preventing cancer or an infection comprising (i) a Usp22 inhibitor and (ii) a pharmaceutically acceptable carrier.
Claims10
A method for activating an immune response in a subject in need thereof, the method comprising administering an inhibitor of ubiquitin-specific peptidase 22 (Usp22 inhibitor) to said subject, wherein the activation of an immune response is treatment of a virus infection, of a bacterial infection, of a fungal infection, or of an autoimmune disease.
A method for identifying a subject susceptible to treatment of disease by administration of a Usp22 inhibitor comprising
- a) determining in a sample of said subject the amount of a Usp22 gene product, of monoubiquitinated H2B (H2Bub1) and/or of an interferon-stimulated gene,
- b) comparing said amount determined in step a) to a reference, and
- c) based on the result of step b), identifying a subject susceptible to treatment of disease by administration of a Usp22 inhibitor,
- wherein said disease is a virus infection, a bacterial infection, or an autoimmune disease.
A method for identifying a compound for activation of an immune response in a subject, comprising
- a) contacting a reaction mixture comprising a Ubiquitin-specific peptidase 22 and Histone 2B-ubiquitin conjugate (H2Bub1) with a compound suspected to have the activity of being an activator of said immune response,
- b) determining the deubiquitination of H2Bub1 in the reaction mixture, and
- c) identifying a compound for activation of an immune response based on the result of the determination step of b).
A method for identifying a compound for activation of an immune response in a subject, comprising
- (A) contacting a host cell with a compound suspected of being an activator of said immune response;
- (B) determining the amount of H2Bub1 and/or of at least one H2Bub1 modulated gene of Table 1 in said host cell;
- (C) comparing the amount or amounts determined in step (B) to a reference or to references;
- and
- (D) identifying a compound for activation of an immune response in a subject based on the result of comparison step (C).
Dependencies are inferred from the claim text.