Mutant of corynebacterium glutamicum with enhanced l-lysine productivity and method for preparing l-lysine using the same
AssigneeDaesang Corporation
InventorsHa Eun Kim, Sun Hee Lee, Young Ju Lee, Seok Hyun Park, Joon Hyun Park
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Abstract
The present disclosure relates to a Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity and a method of producing L-lysine using the same. The mutant strain may produce L-lysine in an improved yield compared to the parent strain by increasing or enhancing the expression of a gene encoding aspartate-semialdehyde dehydrogenase therein.
Claims3
A Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity by a substitution of glycine for alanine at position 35, a substitution of glutamic acid for serine at position 39, and a substitution of valine for alanine at position 78;
- or a substitution of glycine for alanine at position 35, a substitution of leucine for arginine at position 38, a substitution of glutamic acid for serine at position 39, and a substitution of valine for alanine at position 78 in the amino acid sequence of aspartate-semialdehyde dehydrogenase of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.